Resource Type

Journal Article 97

Year

2023 4

2022 8

2021 4

2020 1

2019 3

2018 5

2017 7

2016 3

2015 4

2014 4

2013 2

2012 6

2010 4

2009 5

2008 9

2007 8

2006 4

2005 3

2004 2

2003 2

open ︾

Keywords

characteristic 8

Characteristic 3

COVID-19 2

DX pile 2

Wastewater treatment plant 2

combustion characteristic 2

essential thrombocythemia 2

numerical analysis 2

optimization 2

ANSYS 1

Aerosol transmission 1

Alternate anaerobic/anoxic-aerobic MBR (A2N-MBR) 1

Amplitude-displacement 1

Amplitude-frequency 1

Ball-screw feed drives 1

Biolog 1

C825T polymorphism 1

CRISPR/Cas9 1

Carbon source 1

open ︾

Search scope:

排序： Display mode:

expression are associated with clinical phenotype and clinico-hematological response to hydroxyurea in essential

Frontiers of Medicine 2022, Volume 16, Issue 3,   Pages 403-415 doi: 10.1007/s11684-021-0858-1

Abstract: developed MPN phenotype in myelofibrosis (MF) and secondary AML (sAML) transformed from MPNs versus essential

Keywords： myeloproliferative neoplasms     IRF4     IRF8     hydroxyurea     essential thrombocythemia    

HTML PDF Collect

Efficacy and safety of JAK inhibitor INC424 in patients with primary and post-polycythemia vera or post-essential

Xin Du,Daobin Zhou

Frontiers of Medicine 2016, Volume 10, Issue 4,   Pages 437-443 doi: 10.1007/s11684-016-0472-9

Abstract:

A phase II study (A2202) was performed to evaluate the efficacy and safety of JAK inhibitor ruxolitinib in 63 Chinese MF patients. Ruxolitinib was given twice a day (bid) at a starting dose of 15 mg (n=25) or 20 mg (n=38) based on a baseline platelet count. About 94.7% of the patients achieved a reduction in spleen size, 27.0% of which exhibited significant reduction (≥35%) at week 24. Significant improvement in debilitating constitutional symptoms, as assessed by MFSAF v2.0, was observed in patients treated with ruxolitinib. Ruxolitinib treatment was generally well tolerated by Chinese patients. Although the treatment was associated with an increase in certain adverse events (AEs) that were established as identified risks (anemia and thrombocytopenia), these AEs were considered manageable in this clinical setting. Ruxolitinib provided substantial reductions in splenomegaly and improvements in symptoms, and was well-tolerated by Chinese patients with MF.

Keywords： JAK     ruxolitinib     Chinese patients     myelofibrosis    

HTML PDF Collect

A Study on the Essence of Process Manufacturing

Fan Jiongming,Hu Shanying,Chen Dingjiang,Zhang Qun,Li Jin,Ma Shujie,,Song Xiaoxu,Jin Yong,Chen Bingzhen and Yin Ruiyu

Strategic Study of CAE 2017, Volume 19, Issue 3,   Pages 80-88 doi: 10.15302/J-SSCAE-2017.03.012

Abstract:

Process manufacturing is an important pillar of China's economic development, and its orderly and healthy development is of great significance to China’s economic and social development. However, the development of process manufacturing is constrained by its enormous consumption of resources and energy and its serious environmental impact. To reach a deeper understanding of the future development of process manufacturing, this study extends an analytical perspective from a single industry to all forms of process manufacturing. Based on the concepts of thermodynamics and entropy, this study analyzes the essence of process manufacturing. Three groups of key factors are used to build the analysis framework: flow and process; material, energy, and information; and scale and efficiency. A chemical engineering process and a phosphorus chemical process are then analyzed using this framework. The results show that the fundamental direction of the development of process manufacturing is to minimize the entropy increments of the whole system, rather than only those of the process system, while ignoring the entropy increments of the system of the external environment. In order to minimize the entropy increments of the whole system, it is necessary not only to pay attention to the economic benefits of the process system, but also to improve resource, energy, and environmental efficiency. To improve efficiency, the technology involved requires improvement, upgrading, and innovation. Improving and upgrading the technology can slightly improve the efficiency of a process system, while revolutionary innovation in the technology may greatly improve the efficiency.

Keywords： process manufacturing     entropy     process system     essence     essential characteristic    

HTML PDF Collect

Observation of a higher JAK2 V617F homozygous mutated clone in polycythemia vera compared to essential

LIU Hongxing, TONG Chunrong, CAI Peng, GU Jiangying, LIN Yuehui, TENG Wen, WANG He, ZHANG Ying, ZHU Ping

Frontiers of Medicine 2008, Volume 2, Issue 3,   Pages 309-313 doi: 10.1007/s11684-008-0059-1

Abstract: assays were developed and performed for JAK2V617F detection on 40 polycythemia vera (PV) samples, 31 essential

Keywords： specific amplification     essential thrombocythemia     Single-tube bi-directional     JAK2V617F-positive     JAK2V617F    

HTML PDF Collect

Overlap maximum matching ratio (OMMR): a new measure to evaluate overlaps of essential modules

Xiao-xia ZHANG,Qiang-hua XIAO,Bin LI,Sai HU,Hui-jun XIONG,Bi-hai ZHAO

Frontiers of Information Technology & Electronic Engineering 2015, Volume 16, Issue 4,   Pages 293-300 doi: 10.1631/FITEE.1400282

Abstract: Research shows that overlapping complexes can contribute to identifying essential proteins, which areComparison of essential proteins and gene ontology (GO) analysis are also used to assess the qualityindicate the important of overlaps and reveal the relationship between overlaps and identification of essential

Keywords： Protein-protein interaction network     Essential protein modules     Overlap     Overlap maximum matching ratio    

HTML PDF Collect

Analysis of the dynamic hysteresis characteristic of finger seal

LEI Yanni, CHEN Guoding

Frontiers of Mechanical Engineering 2007, Volume 2, Issue 1,   Pages 32-36 doi: 10.1007/s11465-007-0005-y

Abstract: The research about hysteresis characteristic of finger seal (FS), which was carried out based on theA mass spring damper dynamics model of FS system was proposed and the hysteresis characteristic of theThis work shows that the dynamics characteristic analysis of the FS is necessary and the dynamics model

Keywords： FS     necessary     hysteresis characteristic     optimization     spring    

HTML PDF Collect

A New Way to Study the Three Essential Factors of Forest Fire

Zhao Xianwen

Strategic Study of CAE 2000, Volume 2, Issue 5,   Pages 66-71

Abstract:

This thesis took the three essential factors of forest fire (fire source, environment, and litter)

Keywords： forecast of forest fire     space remote sensing     essential factors of forest fire     a new way    

HTML PDF Collect

Association study on GNB3 gene polymorphism with essential hypertension in Xinjiang Uygur group

JING Jianying, WANG Dan, WANG Xiaofeng, JIN Jianzhong, JIN Li, JIAO Yi, WEN Hao, LIN Renyong

Frontiers of Medicine 2007, Volume 1, Issue 2,   Pages 230-233 doi: 10.1007/s11684-007-0045-z

Abstract: The relationship between the tenth exon C825T of G-protein β3 subunit (GNB) genetic polymorphism and hypertension in the Uygur population of China was investigated. A nested case-control study ( = 738) was carried out. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique was used to genotype GNB C825T polymorphism in 354 hypertensive (HT) and 384 normotensive (NT) Uygur subjects. The distributions of GNB C825T genotypes were CC (27.2%), TT (42.9%), and CT (29.9%) in the hypertensive subjects and CC (27.7%), TT (42.4%), CT (29.9%) in the normotensive subjects. There were no significant differences in the genotype distributions between the two groups ( = 0.0262 P = 0.99). The T allele was 51.4% in hypertensive subjects and 51.2% in normotensive subjects, which, between the two groups, was not a significant difference ( = 0.0016 P = 0.97). Further analysis shows that there is no association between C825T genotypes and age, body mass index (BMI), Glucose (GLU), Triglyceride (TG), Cholesterol (CHO), systolic blood pressure (SBP) and diastolic blood pressure (DBP). No evidence was found to suggest an association between GNB C825T polymorphism and hypertension in the Uygur population of China.

Keywords： case-control     significant difference     reaction-restriction fragment     C825T polymorphism     evidence    

HTML PDF Collect

Reactive oxygen species generation is essential for cisplatin-induced accelerated senescence in hepatocellular

Kai Qu,Ting Lin,Zhixin Wang,Sinan Liu,Hulin Chang,Xinsen Xu,Fandi Meng,Lei Zhou,Jichao Wei,Minghui Tai,Yafeng Dong,Chang Liu

Frontiers of Medicine 2014, Volume 8, Issue 2,   Pages 227-235 doi: 10.1007/s11684-014-0327-1

Abstract:

Accelerated senescence is important because this process is involved in tumor suppression and has been induced by many chemotherapeutic agents. The platinum-based chemotherapeutic agent cisplatin displays a wide range of antitumor activities. However, the molecular mechanism of cisplatin-induced accelerated senescence in hepatocellular carcinoma (HCC) remains unclear. In the present study, the growth inhibitory effect of cisplatin on HepG2 and SMMC-7721 cells was detected by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. Cellular senescence was then assessed by β-galactosidase assay. Senescence-related factors, including p53, p21, and p16, were evaluated by quantitative reverse transcription-polymerase chain reaction. Reactive oxygen species (ROS) was analyzed by flow cytometry. Our results revealed that cisplatin reduced the proliferation of HepG2 and SMMC-7721 cells in a dose- and time-dependent manner. Senescent phenotype observed in cisplatin-treated hepatoma cells was dependent on p53 and p21 activation but not on p16 activation. Furthermore, cisplatin-induced accelerated senescence depended on intracellular ROS generation. The ROS scavenger N-acetyl-L-cysteine also significantly suppressed the cisplatin-induced senescence of HepG2 and SMMC-7721 cells. In conclusion, our results revealed a functional link between intracellular ROS generation and cisplatin-induced accelerated senescence, and this link may be used as a potential target of HCC.

Keywords： reactive oxygen species     senescence     cisplatin     hepatocellular carcinoma    

HTML PDF Collect

Flow characteristic and wastewater treatment performance of a pilot-scale airlift oxidation ditch

Hongtao PANG, Hanchang SHI, Huiming SHI,

Frontiers of Environmental Science & Engineering 2009, Volume 3, Issue 4,   Pages 470-476 doi: 10.1007/s11783-009-0143-z

Abstract: diffuser and baffle as aerator was operated in a wastewater treatment plant (WWTP) to investigate its flow characteristic

Keywords： airlift oxidation ditch     flow characteristic     wastewater treatment    

HTML PDF Collect

Weak characteristic information extraction from early fault of wind turbine generator gearbox

Xiaoli XU, Xiuli LIU

Frontiers of Mechanical Engineering 2017, Volume 12, Issue 3,   Pages 357-366 doi: 10.1007/s11465-017-0423-4

Abstract:

Given the weak early degradation characteristic information during early fault evolution in gearboxA weak characteristic information extraction based on µ-SVD and local mean decompositionExperimental results show that this method can significantly weaken signal noise, effectively extract the weak characteristic

Keywords： wind turbine generator gearbox     µ-singular value decomposition     local mean decomposition     weak characteristic    

HTML PDF Collect

Cybersecurity Research—Essential to a Successful Digital Future

Jackie Craig

Engineering 2018, Volume 4, Issue 1,   Pages 9-10 doi: 10.1016/j.eng.2018.02.006

HTML PDF Collect

Fractal characteristic evaluation and interpolation reconstruction for surface topography of drilled

Frontiers of Mechanical Engineering 2021, Volume 16, Issue 4,   Pages 840-854 doi: 10.1007/s11465-021-0643-5

Abstract: In this paper, an improved fractal interpolation model is proposed to reconstruct the surface topography of composite hole wall. This model adopts the maximum positive deviations and maximum negative deviations between the measured values and trend values to determine the contraction factors. Hole profiles in 24 directions are measured. Fractal parameters are calculated to evaluate the measured surface profiles. The maximum and minimum fractal dimension of the hole wall are 1.36 and 1.07, whereas the maximum and minimum fractal roughness are 4.05 × 10 −5 and 4.36 × 10 −10 m, respectively. Based on the two-dimensional evaluation results, three-dimensional surface topographies in five typical angles (0°, 45°, 90°, 135°, and 165°) are reconstructed using the improved model. Fractal parameter D s and statistical parameters Sa, Sq, and Sz are used to evaluate the reconstructed surfaces. Average error of D s, Sa, Sq, and Sz between the measured surfaces and the reconstructed surfaces are 1.53%, 3.60%, 5.60%, and 9.47%, respectively. Compared with the model in published literature, the proposed model has equal reconstruction effect in relatively smooth surface and is more advanced in relatively rough surface. Comparative results prove that the proposed model for calculating contraction factors is more reasonable.

Keywords： surface topography     fractal evaluation     fractal interpolation     reconstruction     composite    

HTML PDF Collect

Operating characteristic analysis on the ultra-thin low temperature floor-heating system

Hualing ZHANG, Xiaopeng SONG

Frontiers of Structural and Civil Engineering 2013, Volume 7, Issue 2,   Pages 127-132 doi: 10.1007/s11709-013-0200-3

Abstract: However, there is a lack of operating characteristic research in this region, especially the energy consumption

Keywords： ultra-thin floor heating panel     the preheating time     thermal comfort     energy saving    

HTML PDF Collect

Design and characteristic research of a novel electromechanical-hydraulic hybrid actuator with two transmission

Frontiers of Mechanical Engineering 2023, Volume 18, Issue 2, doi: 10.1007/s11465-022-0735-x

Abstract: Servo-hydraulic actuators (SHAs) are widely used in mechanical equipment to drive heavy-duty mechanisms. However, their energy efficiency is low, and their motion characteristics are inevitably affected by uncertain nonlinearities. Electromechanical actuators (EMAs) possess superior energy efficiency and motion characteristics. However, they cannot easily drive heavy-duty mechanisms because of weak bearing capacity. This study proposes and designs a novel electromechanical-hydraulic hybrid actuator (EMHA) that integrates the advantages of EMA and SHA. EMHA mainly features two transmission mechanisms. The piston of the hydraulic transmission mechanism and the ball screw pair of the electromechanical transmission mechanism are mechanically fixed together through screw bolts, realizing the integration of two types of transmission mechanisms. The control scheme of the electromechanical transmission mechanism is used for motion control, and the hydraulic transmission mechanism is used for power assistance. Then, the mathematical model, structure, and parameter design of the new EMHA are studied. Finally, the EMHA prototype and test platform are manufactured. The test results prove that the EMHA has good working characteristics and high energy efficiency. Compared with the valve-controlled hydraulic cylinder system, EMHA exhibits a velocity tracking error and energy consumption reduced by 49.7% and 54%, respectively, under the same working conditions.

Keywords： electromechanical-hydraulic hybrid actuator (EMHA)     integration     transmission mechanisms     power assistance     energy efficiency     working characteristics    

HTML PDF Collect

Title Author Date Type Operation

expression are associated with clinical phenotype and clinico-hematological response to hydroxyurea in essential

Journal Article

Efficacy and safety of JAK inhibitor INC424 in patients with primary and post-polycythemia vera or post-essential

Xin Du,Daobin Zhou

Journal Article

A Study on the Essence of Process Manufacturing

Fan Jiongming,Hu Shanying,Chen Dingjiang,Zhang Qun,Li Jin,Ma Shujie,,Song Xiaoxu,Jin Yong,Chen Bingzhen and Yin Ruiyu

Journal Article

Observation of a higher JAK2 V617F homozygous mutated clone in polycythemia vera compared to essential

LIU Hongxing, TONG Chunrong, CAI Peng, GU Jiangying, LIN Yuehui, TENG Wen, WANG He, ZHANG Ying, ZHU Ping

Journal Article

Overlap maximum matching ratio (OMMR): a new measure to evaluate overlaps of essential modules

Xiao-xia ZHANG,Qiang-hua XIAO,Bin LI,Sai HU,Hui-jun XIONG,Bi-hai ZHAO

Journal Article

Analysis of the dynamic hysteresis characteristic of finger seal

LEI Yanni, CHEN Guoding

Journal Article

A New Way to Study the Three Essential Factors of Forest Fire

Zhao Xianwen

Journal Article

Association study on GNB3 gene polymorphism with essential hypertension in Xinjiang Uygur group

JING Jianying, WANG Dan, WANG Xiaofeng, JIN Jianzhong, JIN Li, JIAO Yi, WEN Hao, LIN Renyong

Journal Article

Reactive oxygen species generation is essential for cisplatin-induced accelerated senescence in hepatocellular

Kai Qu,Ting Lin,Zhixin Wang,Sinan Liu,Hulin Chang,Xinsen Xu,Fandi Meng,Lei Zhou,Jichao Wei,Minghui Tai,Yafeng Dong,Chang Liu

Journal Article

Flow characteristic and wastewater treatment performance of a pilot-scale airlift oxidation ditch

Hongtao PANG, Hanchang SHI, Huiming SHI,

Journal Article

Weak characteristic information extraction from early fault of wind turbine generator gearbox

Xiaoli XU, Xiuli LIU

Journal Article

Cybersecurity Research—Essential to a Successful Digital Future

Jackie Craig

Journal Article

Fractal characteristic evaluation and interpolation reconstruction for surface topography of drilled

Journal Article

Operating characteristic analysis on the ultra-thin low temperature floor-heating system

Hualing ZHANG, Xiaopeng SONG

Journal Article

Design and characteristic research of a novel electromechanical-hydraulic hybrid actuator with two transmission

Journal Article